Hi bryangarberg, sorry we are so late replying to you. We have been a bit overwhelmed just recently. First, welcome to the Sonos community. To answer your question, we would not recommend using different kinds of speakers on the CONNECT:AMP as a general rule, but if those Bose ones are rated for 8Ohms, then it's fine to use them with the Yamaha 8Ohm speakers.

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