Depends on the strength of the signal from the mifi device, more so than the Sonos speakers ability to receive a signal. 

I can tell you Sonos works just fine in an average size home, using a T-Mobile WiFi producing device, with no dead spots. This is a timber framed, average home, using plaster board walls. 

But the real question is, what are the possibilities of potential wifi interference in your situation? From the strength of the transmission, to the reflection of the matter between the emitting device and the receiving device(s). You’re asking a question none of us can effectively answer, your own testing will be the ultimate guide. 

Just as a note, though, the Era 100 doesn’t create a SonosNet signal, it instead relies on WiFi itself. 

Moderator edit: combined two posts.

Don't know the MiFi, any chance you could use a WiFi Travel Router connected to the campus network to provide the LAN environmemt Sonos needs?

Either WiFi mode or wired to each Sonos if out of range. Long Ethernet cables are cheap, Amazon Basics or the like do fine.

Thanks for advice.  I’ll try the suggestions.  Does anyone know if a 5G Mobile Portable WiFi | Verizon Wireless Jetpack Inseego MiFi M1000 | Mobile Hotspot for Travel | RJ45 Ethernet Port | Speed Up to 2,4 Gbps | Use 8 hrs | EVDO-LINK Bundle - Verizon Sim Card  would perform better in my SONOs speaker environment than my current older 4G mifi.  I guess I’m asking if the 5G portable would have a stronger wifi signal to the SONOs speaker than my current 4G mifi?

Depends on what tower signal you receive for the internet speed. In general, 5G is faster than 4G, but there’s a lot in that statement that has to do with the signal strength path/connection. Which means it’s hard to say. Also, in general, newer devices tend to have better electronics in them, which means faster speed. Which actually isn’t a huge issue, streaming music is relatively low bandwidth. You’re more concerned about each speaker’s connection to the ‘router’, than the speed of the connection to the outside world, these days. The question remains as I suggested in my original answer, I.e things depend more on how many devices can connect to the ‘router’, and how strong the signal is, along with how much potential wifi interference there might be.