IIRC, the Harmony 650 is only infrared. You could program it to control the volume and mute on a Playbar or Playbase, but those are the only functions those two Sonos devices understand through infrared.
If you had a Harmony remote + Hub combination (there are several remotes that work with the Harmony Hub), the Hub can send commands to any Sonos device over its WiFi connection, so you could play/pause, skip forward/back, and I think you can even have it play a favorite station or playlist.
The S in IOT stands for Security.