Yes, this setup will work with the Samsung Frame TV. You will need two Amps - one to power the two front in-wall speakers and one to power the two rear in-ceiling speakers. The first Amp will connect to the TV (One Connect box) via HDMI ARC. The second Amp will communicate wirelessly with the first Amp.
You should consider adding a Sonos Sub to complete the 4.1 setup.
NOTE: It is usually recommended to place rear surround speakers at ear level, so you might also consider doing a pair of in-wall speakers for the surrounds rather than in-ceiling speakers.
Thank you. We are in the middle of our home construction and want to wire everything now. I will look at our room layout again and see if wall speakers for the rear will work and also get a Sub.
Also, our rear ceiling speakers if we go that route will be mounted on the lower part of a vaulted ceiling angled toward the television. I’m not sure if that would help for not being wall mounted.
If your home uses conventional drywall construction, there are various “invisible” speakers that can be incorporated into the drywall.