In order to send content to the system? You’d need a line in. And all Sonos analog line ins are subject to a 75 Ms minimum delay. It’s not really a good PA speaker, not designed for that kind of use at all.

 You can add a voice assistant to Sonos, such as Amazon Alexa, Sonos Voice Service, or Google Assistant, in some cases, but that’s for co trol of the music, mostly, and not voice reproduction purposes, or Zoom calls, etc. 

Some SONOS models could accept a Bluetooth wireless microphone, but I don’t think that you will enjoy the results due to the latency mentioned above.