It’s difficult to say without knowing where all your furniture is. But put them in the room where you listen to music the most. And keep them as a stereo pair if possible. If this isn’t possible, put one in the dining room and one in the living room.

For one sweet spot and decent sound elsewhere a properly positioned (to your listening position) stereo pair.

For filling all that space, set them as two Rooms and group them. I’d put one in the dining room at the top right and the other in the living room at the bottom left as a first try.

Keep in mind they are easy to move about to find your best placement.

Do run TruePlay (if you have a compatible Apple device) after every move.