Yes as long as you have them set up as two different Sonos Rooms.

Ungroup them if they are Grouped and select what you want to hear on each.

No if you have them in a single Sonos Home Theater Room.

Thanks for the quick reply. 

I have them upaired now, arc playing tv. I can see the era100, but shows "No Content".  How do I get my music from phone, or Pandora or similar to playing?

Thanks again 

Select the 100s Room from the Now Playing screen.

Tap something under Recently Played, Sonos Favorits or Your Services.

Same to play on the Arc. 

Thanks for all the help and answers. I have it dialed in now.