No. You’d need to factory reset the speakers you’re leaving behind, and they’d need to set them up on their own accounts. The app doesn’t store any (significant) data, it’s all stored on the speakers. Unless you factory reset them, they’ll remain on your account. 

Thanks for following up, @Airgetlam . Conversely, could I hard reset the Sonos speaker I take with me and set this up as a new system in the new location? This way, my profile could be linked to two different systems in two locations, correct?

Yes. Any number of ‘house holds’ can be associated with a Sonos account, since there’s no ‘cloud’ data associated with the account. All of the pertinent information is stored on each speaker system.