Best answer by UKMedia
5.1 is only supported via a Playbar or Playbase paired with either x2 of the same of: Play:1's, Sonos Ones, Play:3's or Play:5's. Without the Playbar or Playbase, the most you can achieve is a paired Stereo pair.
You can move your players around but I try not to separate a Stereo pair because of the time taken to calibrate via TruePlay (This balances the Audio from each of the Speakers). Regardless of how many Players you purchase, you have the ability to sync the same music throughout all rooms or play different music on each room.